The DYT6 dystonia causative protein THAP1 is responsible for proteasome activity via PSMB5 transcriptional regulation

Abstract The proteasome plays a pivotal role in protein degradation, and its impairment is associated with various pathological conditions, including neurodegenerative diseases. It is well understood that Nrf1 coordinates the induction of all proteasome genes in response to proteasome dysfunction. H...

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Detalhes bibliográficos

Principais autores:	Yan Wang, Yi Wang, Tomohiro Iriki, Eiichi Hashimoto, Maki Inami, Sota Hashimoto, Ayako Watanabe, Hiroshi Takano, Ryo Motosugi, Shoshiro Hirayama, Hiroki Sugishita, Yukiko Gotoh, Ryoji Yao, Jun Hamazaki, Shigeo Murata
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-02-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-56867-x
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