Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution

Abstract Blood brain barrier-crossing molecules targeting transferrin receptor (TfR) and CD98 heavy chain (CD98hc) are widely reported to promote enhanced brain delivery of therapeutics. Here, we provide a comprehensive and unbiased biodistribution characterization of TfR and CD98hc antibody transpo...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Nathalie Khoury, Michelle E. Pizzo, Claire B. Discenza, David Joy, David Tatarakis, Mihail Ivilinov Todorov, Moritz Negwer, Connie Ha, Gabrielly L. De Melo, Lily Sarrafha, Matthew J. Simon, Darren Chan, Roni Chau, Kylie S. Chew, Johann Chow, Allisa Clemens, Yaneth Robles-Colmenares, Jason C. Dugas, Joseph Duque, Doris Kaltenecker, Holly Kane, Amy Leung, Edwin Lozano, Arash Moshkforoush, Elysia Roche, Thomas Sandmann, Mabel Tong, Kaitlin Xa, Yinhan Zhou, Joseph W. Lewcock, Ali Ertürk, Robert G. Thorne, Meredith E. K. Calvert, Y. Joy Yu Zuchero
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-02-01
Colecção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-57108-x
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!