Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron

Abstract Background Intrinsic fitness costs are likely to have guided the selection of lineage-determining mutations during emergence of variants of SARS-CoV-2. Whereas changes in receptor affinity and antibody neutralization have been thoroughly mapped for individual mutations in spike, their influ...

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Detalhes bibliográficos

Principais autores:	Simon Schröder, Anja Richter, Talitha Veith, Jackson Emanuel, Luca Gudermann, Kirstin Friedmann, Lara M. Jeworowski, Barbara Mühlemann, Terry C. Jones, Marcel A. Müller, Victor M. Corman, Christian Drosten
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-11-01
coleção:	Virology Journal
Assuntos:	COVID-19 SARS-CoV-2 Reverse genetics Virus fitness Antibody neutralization escape Spike protein evolution
Acesso em linha:	https://doi.org/10.1186/s12985-023-02154-4
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