Identifying and Engineering Bottlenecks of Autotrophic Isobutanol Formation in Recombinant C. ljungdahlii by Systemic Analysis

Clostridium ljungdahlii (C. ljungdahlii, CLJU) is natively endowed producing acetic acid, 2,3-butandiol, and ethanol consuming gas mixtures of CO2, CO, and H2 (syngas). Here, we present the syngas-based isobutanol formation using C. ljungdahlii harboring the recombinant amplification of the “Ehrlich...

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Autori principali:	Maria Hermann, Attila Teleki, Sandra Weitz, Alexander Niess, Andreas Freund, Frank Robert Bengelsdorf, Peter Dürre, Ralf Takors
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2021-03-01
Serie:	Frontiers in Bioengineering and Biotechnology
Soggetti:	Clostridium ljungdahlii intracellular metabolite pools synthesis gas fermentation recombinant product formation isobutanol
Accesso online:	https://www.frontiersin.org/articles/10.3389/fbioe.2021.647853/full
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