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Formyl peptide receptor 2 activation by mitochondrial formyl peptides stimulates the neutrophil proinflammatory response via the ERK pathway and exacerbates ischemia–reperfusion injury

Abstract Background Ischemia–reperfusion injury (IRI) is an inevitable process in renal transplantation that significantly increases the risk of delayed graft function, acute rejection, and even graft loss. Formyl peptide receptor 2 (FPR2) is an important receptor in multiple septic and aseptic inju...

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Principais autores: Yirui Cao, Juntao Chen, Feng Liu, Guisheng Qi, Yufeng Zhao, Shihao Xu, Jiyan Wang, Tongyu Zhu, Yi Zhang, Yichen Jia
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2023-01-01
סדרה:Cellular & Molecular Biology Letters
נושאים:
Formyl peptide receptor 2
Neutrophil
Kidney IRI
Migration
Mitochondrial-derived formyl peptides
גישה מקוונת:https://doi.org/10.1186/s11658-023-00416-1
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