Comprehensive assessment of activity, specificity, and safety of hypercompact TnpB systems for gene editing
Abstract Background As the ancestor of CRISPR-Cas12 nucleases, TnpB represents the most compact gene editing tool currently available. Recent studies have identified multiple TnpB systems with gene editing activity in mammalian cells, and the potential of TnpB in treating diseases has been demonstra...
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| Principais autores: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2026-01-01
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| coleção: | Genome Biology |
| Acesso em linha: | https://doi.org/10.1186/s13059-026-03949-8 |
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