The Optimal Permeation of Cyclic Boronates to Cross the Outer Membrane via the Porin Pathway

We investigated the diffusion of three cyclic boronates formulated as beta-lactamase inhibitors through the porin OmpF to evaluate their potential to cross OM via the porin pathway. The three nonbeta-lactam molecules diffuse through the porin eyelet region with the same mechanism observed for beta-l...

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Hlavní autoři:	Gian Marco Tuveri, Matteo Ceccarelli, Alessandro Pira, Igor V. Bodrenko
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2022-06-01
Edice:	Antibiotics
Témata:	cyclic boronates beta-lactamase inhibitors porins permeation diffusion current molecular dynamics simulations
On-line přístup:	https://www.mdpi.com/2079-6382/11/7/840
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