Within-host evolution drives the emergence of ceftazidime-avibactam resistance mediated by IncN plasmid-encoded blaNDM-1 and blaKPC-33 in ST11-KL64 hypervirulent Klebsiella pneumoniae

ABSTRACT Ceftazidime-avibactam (CZA) is considered one of the most effective antimicrobial agents for treating infections caused by Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae. However, rising CZA resistance poses a critical clinical challenge, primarily driven by blaKPC muta...

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Detalhes bibliográficos

Principais autores:	Peiwen Xia, Na Huang, Tingting Si, Shiyu Tang, Qi Han, Yuqiong Li, Yuanyuan Song, Yingyi Liu, Yun Xia
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2026-04-01
Colecção:	Microbiology Spectrum
Assuntos:	KPC-producing hypervirulent Klebsiella pneumoniae ceftazidime-avibactam blaNDM-1 IncN blaKPC-33 adaptive evolution
Acesso em linha:	https://journals.asm.org/doi/10.1128/spectrum.02367-25
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