Estradiol increases risk of topoisomerase IIβ-mediated DNA strand breaks to initiate Xp11.2 translocation renal cell carcinoma

Abstract Background Xp11.2 translocation renal cell carcinoma (tRCC) is defined by translocation of the transcription factor E3 (TFE3) gene located on chromosome Xp11.2. Due to the high incidence in women, 17β-estradiol (E2) may be a factor influencing TFE3 breaks, and the topoisomerase II (TOP2) po...

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Auteurs principaux:	Qiancheng Shi, Ning Liu, Lei Yang, Yi Chen, Yanwen Lu, Hongqian Guo, Xiaodong Han, Dongmei Li, Weidong Gan
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2021-11-01
Collection:	Cell Communication and Signaling
Sujets:	Renal cell carcinoma Xp11.2 Estradiol Estrogen receptor Topoisomerase TFE3
Accès en ligne:	https://doi.org/10.1186/s12964-021-00790-3
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