Directly reprogrammed fragile X syndrome dorsal forebrain precursor cells generate cortical neurons exhibiting impaired neuronal maturation

IntroductionThe neurodevelopmental disorder fragile X syndrome (FXS) is the most common monogenic cause of intellectual disability associated with autism spectrum disorder. Inaccessibility to developing human brain cells is a major barrier to studying FXS. Direct-to-neural precursor reprogramming pr...

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Bibliografiset tiedot

Päätekijät:	Nicole Edwards, Catharina Combrinck, Amy McCaughey-Chapman, Bronwen Connor
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Frontiers Media S.A. 2023-09-01
Sarja:	Frontiers in Cellular Neuroscience
Aiheet:	fragile X syndrome direct reprogramming neurodevelopment dorsal progenitor cortical neuron methylation
Linkit:	https://www.frontiersin.org/articles/10.3389/fncel.2023.1254412/full
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