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Braking Parkinson’s progression: the hypothetical druggable role of striatal parvalbumin interneurons

Abstract The striatum is one of the first brain regions affected in Parkinson’s disease (PD), where dopaminergic axons projecting from the substantia nigra undergo dying-back degeneration. Growing evidence shows that dopamine depletion triggers network-level remodeling in the striatum, whose patholo...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Quansheng He, Xuan Wang, Xiaowen Zhang, Yousheng Shu
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2026-04-01
Rangatū:npj Parkinson's Disease
Urunga tuihono:https://doi.org/10.1038/s41531-026-01303-0
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