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In vitro cytoprotective and in vivo anti-oral mucositis effects of melatonin and its derivatives

According to our preliminary study, melatonin and its N-amide derivatives (N-(2-(1-4-bromobenzoyl-5-methoxy-1H-indol-3-yl)ethyl)acetamide (BBM) and 4-bromo-N-(2-(5-methoxy-1H-indol-3-yl)ethyl)benzamide (EBM)) inhibited the marker of acute inflammation in tests in vitro and in vivo. The anti-inflamma...

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Main Authors: Pramote Mahakunakorn, Pimpichaya Sangchart, Panyada Panyatip, Juthamat Ratha, Teerasak Damrongrungruang, Aroonsri Priprem, Ploenthip Puthongking
Format: Artigo
Language:Inglês
Published: PeerJ Inc. 2024-07-01
Series:PeerJ
Subjects:
Melatonin
Amide derivatives
5-Fluorouracil
Oral mucositis
Chemotherapy
Cytoprotective
Online Access:https://peerj.com/articles/17608.pdf
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