Breast cancer bone metastasis and bone metastatic cells retain NKG2DLs intracellularly: could this be a strategy to evade immune recognition?

Bone metastases dramatically worsen breast cancer (BC) prognosis reducing overall survival. Natural killer (NK) cells recognize and eliminate malignant cells through the interaction with NKG2D receptor ligands (NKG2DLs) on cancer cells. Tumors often evade NK surveillance by downregulating the NKG2DL...

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Autores principales:	Marta Gomarasca, Paola Maroni, Chiara Verdelli, Laura Gerosa, Martina Faraldi, Alessandro Luzzati, Luca Cannavò, Giuseppe Banfi, Giovanni Lombardi
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2026-01-01
Colección:	Frontiers in Cell and Developmental Biology
Materias:	bone metastasis breast cancer breast cancer immune evasion NK NKG2D NKG2DLs
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1717607/full
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