The metabolic consequences of evoked spreading depolarization in brain slices

Abstract Spreading depolarization is a wave of neuronal and glial depolarization that propagates through brain tissue, triggering neuropeptide release and altered blood flow. It has been observed in ischemic stroke, traumatic brain injury, subarachnoid haemorrhage, epilepsy, and migraine aura. Sprea...

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Autores principales:	Olivia Grech, Caroline Mugo, Lisa J. Hill, Samuel R. Heaselgrave, Zerin Alimajstorovic, Andreas Yiangou, Hannah S. Lyons, James Mitchell, Gareth G. Lavery, Daniel Fulton, Alexandra J. Sinclair
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-02-01
Colección:	Scientific Reports
Materias:	Spreading depolarization Mitochondrial function Central carbon metabolism Glucose deprivation Coenzyme Q10 Multi electrode array
Acceso en línea:	https://doi.org/10.1038/s41598-026-37175-w
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