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The neutralizing effect of heparin on blood-derived antimicrobial compounds: impact on antibacterial activity and inflammatory response

Acting through a combination of direct and indirect pathogen clearance mechanisms, blood-derived antimicrobial compounds (AMCs) play a pivotal role in innate immunity, safeguarding the host against invading microorganisms. Besides their antimicrobial activity, some AMCs can neutralize endotoxins, pr...

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Huvudupphov: Denisa Cont, Stephan Harm, Claudia Schildböck, Claudia Kolm, Alexander K. T. Kirschner, Andreas H. Farnleitner, Matthias Pilecky, Jennifer Zottl, Jens Hartmann, Viktoria Weber
Materialtyp: Artigo
Språk:Inglês
Utgiven: Frontiers Media S.A. 2024-03-01
Serie:Frontiers in Immunology
Ämnen:
antibacterial activity
antimicrobial compounds
endotoxin neutralization
host defense peptides
heparin
LPS
Länkar:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1373255/full
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