Hydrogen sulfide acts as a sulfur source for iron sulfur cluster biosynthesis in cysteine desulfurase-deficient Escherichia coli under anaerobic conditions

The cysteine desulfurase (IscS) is a core component of the ISC iron–sulfur (Fe-S) cluster assembly system in Escherichia coli. Deficiency of IscS leads to serious growth defects in E. coli, along with reduced activity of Fe-S cluster-dependent enzymes. We previously demonstrated that the growth defe...

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Detalhes bibliográficos

Principais autores:	Heng Li, Jun Wang, Xiaorui Li, Guanya Jia, Haisheng Gan, Yanxiong Wang, Zhiwei Ma, Zhilong Zhu, Xiaoya Shang, Weining Niu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-03-01
coleção:	Frontiers in Microbiology
Assuntos:	anaerobic conditions cysteine desulfurase IscS Escherichia coli hydrogen sulfide iron–sulfur cluster scaffold protein IscU
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmicb.2026.1759970/full
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