Inhibition of a prokaryotic GH78 α-l-rhamnosidase by synthetic pyrrolidines compared to a eukaryotic α-l-rhamnosidase from Penicillium decumbens

This study presents the first evaluation of diverse iminosugars as inhibitors of a prokaryotic GH78 α-l-rhamnosidase. The pyrrolidine derivatives acted as enzyme competitive inhibitors. The most effective inhibitors were the N-(p-iodo)benzyl derivatives of 1,4-dideoxy-1,4-imino-l-lyxitol and 1,4,6-t...

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Detalhes bibliográficos

Principais autores:	Vladimír Puchart, Tomáš Klunda, Monika Poláková
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-07-01
coleção:	Results in Chemistry
Assuntos:	Bacterial α-l-rhamnosidase Glycoside hydrolase family 78 Iminosugar Pyrrolidine Competitive inhibition
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211715626004716
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