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Transcription coupled repair and biased insertion of human retrotransposon L1 in transcribed genes

Abstract Background L1 retrotransposons inserted within genes in the human genome show a strong bias against sense orientation with respect to the gene. One suggested explanation for this observation was the possibility that L1 inserted randomly, but that there was negative selection against sense-o...

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Hlavní autoři: Geraldine Servant, Vincent A. Streva, Prescott L. Deininger
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2017-12-01
Edice:Mobile DNA
Témata:
L1 retrotransposon
Transcription-coupled repair
Target-primed reverse transcription
DNA repair
Mutagenesis
On-line přístup:http://link.springer.com/article/10.1186/s13100-017-0100-5
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