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The ST2+ Treg/amphiregulin axis protects from immune-mediated hepatitis

IntroductionThe alarmin IL-33 has been implicated in the pathology of immune-mediated liver diseases. IL-33 activates regulatory T cells (Tregs) and type 2 innate lymphoid cells (ILC2s) expressing the IL-33 receptor ST2. We have previously shown that endogenous IL-33/ST2 signaling activates ILC2s th...

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Principais autores: Selina Wachtendorf, Fitriasari Jonin, Aaron Ochel, Fabian Heinrich, Astrid M. Westendorf, Gisa Tiegs, Katrin Neumann
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-03-01
Serier:Frontiers in Immunology
Fag:
Treg maintenance and function
ST2+ Tregs
ILC2s
amphiregulin
hepatic immunoregulation
liver inflammation
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1351405/full
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