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Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature

Abstract The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells. SASP factors induce tissue remodeling and immune cell recruitment. Previous studies have focused...

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Main Authors: Shangkun Zhao, Zhi Qiao, Roman Pfeifer, Hans-Christoph Pape, Keya Mao, Hai Tang, Bin Meng, Songfeng Chen, Hongjian Liu
Format: Artigo
Language:Inglês
Published: BMC 2024-01-01
Series:European Journal of Medical Research
Subjects:
Fracture healing
Bone
Senescence
SASP
Senolytics
Online Access:https://doi.org/10.1186/s40001-023-01604-7
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