Doxorubicin-mediated testicular toxicity is associated with dysregulated mTOR/Beclin-1 pathways, oxidative stress, inflammation and apoptosis in Wistar rats: preventive role of lutein

Abstract Background Lutein offers undoubted hope for preventing doxorubicin uncharacteristic reproductive function which remains a worldwide health concern in cancer chemotherapy. However, the mechanisms underlying the effect of lutein on maintaining the male reproductive milieu have not yet been fu...

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Autors principals:	Jennifer Efe Jaiyeoba-Ojigho, Jerome Ndudi Asiwe, Joseph Chimezie, Blessing Oluwakemi Abe, Oghenemarho Monalisa Ataikiru, Taniyohwo Mamerhi Enaohwo, Alexander Obidike Naiho, Lilian Ebele Chris-Ozoko, Godstime Jesukobiruo Ibada, Sylvester Ifeakachukwu Okuepusu, Favour Isioma Ikukaiwe, Winnie Taiye Ogwu
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-06-01
Col·lecció:	Laboratory Animal Research
Matèries:	Lutein Doxorubicin Steroidogenesis Testicular toxicity Autophagy
Accés en línia:	https://doi.org/10.1186/s42826-025-00249-3
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