Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model

Abstract Background The first pathology observed in Parkinson’s disease (PD) is ‘dying back’ of striatal dopaminergic (DA) terminals. Connexin (Cx)30, an astrocytic gap junction protein, is upregulated in the striatum in PD, but its roles in neurodegeneration remain elusive. We investigated Cx30 fun...

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Autori principali:	Atsushi Fujita, Hiroo Yamaguchi, Ryo Yamasaki, Yiwen Cui, Yuta Matsuoka, Ken-ichi Yamada, Jun-ichi Kira
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2018-08-01
Serie:	Journal of Neuroinflammation
Soggetti:	Parkinson’s disease Dopaminergic neuron Astrocyte Connexin 30 MPTP
Accesso online:	http://link.springer.com/article/10.1186/s12974-018-1251-0
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