Disulfiram alleviates acute lung injury and related intestinal mucosal barrier impairment by targeting GSDMD-dependent pyroptosis

Abstract Background Pyroptosis was implicated in acute lung injury (ALI). Disulfiram is reported as an effective pyroptosis inhibitor by inhibiting gasdermin D(GSDMD). However, the function of pyroptosis executor GSDMD and treatment of disulfiramon on ALI, especially whether it was involved in ALI-a...

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Hauptverfasser:	Jiping Zhao, Hong Wang, Jintao zhang, Fuwei Ou, Junfei Wang, Tian Liu, Jinxiang Wu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2022-10-01
Schriftenreihe:	Journal of Inflammation
Schlagworte:	Acute lung injury Intestinal mucosal barrier impairment Pyroptosis GSDMD Disulfiram Inflammation
Online-Zugang:	https://doi.org/10.1186/s12950-022-00313-y
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