Targeted mRNA Decay by RNA Binding Protein AUF1 Regulates Adult Muscle Stem Cell Fate, Promoting Skeletal Muscle Integrity

Following skeletal muscle injury, muscle stem cells (satellite cells) are activated, proliferate, and differentiate to form myofibers. We show that mRNA-decay protein AUF1 regulates satellite cell function through targeted degradation of specific mRNAs containing 3′ AU-rich elements (AREs). auf1−/−...

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Autores principales:	Devon M. Chenette, Adam B. Cadwallader, Tiffany L. Antwine, Lauren C. Larkin, Jinhua Wang, Bradley B. Olwin, Robert J. Schneider
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2016-08-01
Colección:	Cell Reports
Materias:	AUF1 AU-rich elements mRNA decay satellite cells muscle stem cells muscle regeneration
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2211124716308646
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