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Multi-omics analysis based on 3D-bioprinted models innovates therapeutic target discovery of osteosarcoma

Current in vitro models for osteosarcoma investigation and drug screening, including two-dimensional (2D) cell culture and tumour spheroids (i.e. cancer stem-like cells), lack extracellular matrix (ECM). Therefore, results from traditional models may not reflect real pathological processes in genuin...

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Principais autores: Yixuan Lin, Yiqi Yang, Kai Yuan, Shengbing Yang, Shuhong Zhang, Hanjun Li, Tingting Tang
Format: Artigo
Sprog:Inglês
Udgivet: KeAi Communications Co., Ltd. 2022-12-01
Serier:Bioactive Materials
Fag:
Bioprinting
Osteosarcoma
In vitro model
Multi-omics
Drug screening
3D culture
Online adgang:http://www.sciencedirect.com/science/article/pii/S2452199X22001451
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