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Repetitive Neonatal Erythropoietin and Melatonin Combinatorial Treatment Provides Sustained Repair of Functional Deficits in a Rat Model of Cerebral Palsy

Cerebral palsy (CP) is the leading cause of motor impairment for children worldwide and results from perinatal brain injury (PBI). To test novel therapeutics to mitigate deficits from PBI, we developed a rat model of extreme preterm birth (<28 weeks of gestation) that mimics dual intrauterine inj...

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Principais autores: Lauren L. Jantzie, Akosua Y. Oppong, Fatu S. Conteh, Tracylyn R. Yellowhair, Joshua Kim, Gabrielle Fink, Adam R. Wolin, Frances J. Northington, Shenandoah Robinson
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-04-01
coleção:Frontiers in Neurology
Assuntos:
cerebral palsy
chorioamnionitis
hypoxia-ischemia
inflammation
social interaction
gait
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fneur.2018.00233/full
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