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A phase 1b open-label, dose-escalating study of safety and efficacy of disulfiram, copper and vinorelbine in advanced solid tumors

Abstract Introduction Disulfiram (DSF) is an inhibitor of acetaldehyde dehydrogenase and is currently used for the treatment of alcoholism. Preclinical studies have shown that the DSF metabolite dithiocarbamate, can bind to copper (Cu) and form bis-(diethyldithiocarbamate)-copper (CuET) that has ant...

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Principais autores: Rikke Løvendahl Eefsen, Jan Stenvang, Jiri Bartek, Per Pfeiffer, Line Tarpgaard, Susann Theile, Nils Brünner, Dorte L. Nielsen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-02-01
coleção:BMC Cancer
Assuntos:
Disulfiram
Copper
Cancer
Efflux pumps
Vinorelbine
Resistance mechanism
Acesso em linha:https://doi.org/10.1186/s12885-026-15743-7
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