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Folic acid-modified Exosome-PH20 enhances the efficiency of therapy via modulation of the tumor microenvironment and directly inhibits tumor cell metastasis

High accumulation of hyaluronan (HA) in the tumor microenvironment leads to an increase in the interstitial pressure and reduction perfusion of drugs. Furthermore, high molecular-weight (HMW)-HA suppresses M1 macrophage polarization, enhances M2 polarization, and induces immunosuppression. Hyaluroni...

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Principais autores: Chunxiang Feng, Zhiyong Xiong, Cheng Wang, Wen Xiao, Haibing Xiao, Kairu Xie, Ke Chen, Huageng Liang, Xiaoping Zhang, Hongmei Yang
Format: Artigo
Sprog:Inglês
Udgivet: KeAi Communications Co., Ltd. 2021-04-01
Serier:Bioactive Materials
Fag:
Hyaluronidase
Exosomes
Tumor microenvironment
Metastasis
Tumor immunotherapy
Online adgang:http://www.sciencedirect.com/science/article/pii/S2452199X20302322
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