Bone marrow fluid enhances the osteogenic activity of induced membrane leading to spontaneous osteogenesis: experimental validation and application in tibiofibular fusion for support reconstruction of segmental tibial defects

Abstract Background Managing large bone defects remains a significant clinical problem. We enhanced the osteogenic activity of the induced membrane (IM) by incorporating bone marrow fluid, leading to spontaneous osteogenesis (SO). We aimed to explore the application of this method in tibiofibular fu...

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Hlavní autoři:	Qudong Yin, Xueming Chen, Shihao Du, Xuming Wei, Yongwei Wu, Fanyu Bu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-02-01
Edice:	Journal of Translational Medicine
Témata:	Bone defect Induced membrane Tibiofibular fusion Spontaneous osteogenesis Bone marrow
On-line přístup:	https://doi.org/10.1186/s12967-024-05840-1
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