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Frequency- and spike-timing-dependent mitochondrial Ca2+ signaling regulates the metabolic rate and synaptic efficacy in cortical neurons

Mitochondrial activity is crucial for the plasticity of central synapses, but how the firing pattern of pre- and postsynaptic neurons affects the mitochondria remains elusive. We recorded changes in the fluorescence of cytosolic and mitochondrial Ca2+ indicators in cell bodies, axons, and dendrites...

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Principais autores: Ohad Stoler, Alexandra Stavsky, Yana Khrapunsky, Israel Melamed, Grace Stutzmann, Daniel Gitler, Israel Sekler, Ilya Fleidervish
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2022-02-01
Serier:eLife
Fag:
cortical pyramidal neuron
spike-timing-dependent plasticity
mitochondria
Ca2+ signaling
axon
dendrite
Online adgang:https://elifesciences.org/articles/74606
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