Isolation of human monoclonal antibodies from 4CMenB vaccinees reveals PorB and LOS as the main OMV components inducing cross-strain protection

IntroductionThe 4CMenB vaccine licensed against serogroup B Neisseria meningitidis (MenB) contains three recombinant proteins and Outer Membrane Vesicles (OMV) from a New Zealand epidemic strain. The protective response mediated on differentmeningococcal strains has been historically ascribed to one...

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Principais autores:	Giacomo Vezzani, Viola Viviani, Martina Audagnotto, Alessandro Rossi, Paolo Cinelli, Nicola Pacchiani, Chiara Limongi, Laura Santini, Fabiola Giusti, Sara Tomei, Giulia Torricelli, Elisa Faenzi, Chiara Sammicheli, Simona Tavarini, Adriana Efron, Alessia Biolchi, Oretta Finco, Isabel Delany, Elisabetta Frigimelica
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-04-01
coleção:	Frontiers in Immunology
Assuntos:	4CMenB outer membrane vesicles PorB lipooligosaccharides (LOS) cross-strain protection human monoclonal antibodies
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565862/full
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