Loss of popdc3 Impairs Mitochondrial Function and Causes Skeletal Muscle Atrophy and Reduced Swimming Ability in Zebrafish

ABSTRACT Background The Popeye domain containing 3 (POPDC3) protein is essential for the maintenance of skeletal muscle homeostasis. POPDC3 is a pathogenic variant gene of limb‐girdle muscular dystrophy (LGMD), and its variants lead to LGMDR26. At the animal level, zebrafish larvae with popdc3 mutat...

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Autors principals:	Chen‐Chen Sun, Zhang‐Lin Chen, Dong Yang, Jiang‐Ling Xiao, Xiang‐Tao Chen, Xi‐Yang Peng, Xiu‐Shan Wu, Chang‐Fa Tang
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2025-04-01
Col·lecció:	Journal of Cachexia, Sarcopenia and Muscle
Matèries:	mitochondrial dysfunction POPDC3 protein homeostasis skeletal muscle atrophy skeletal muscle mass
Accés en línia:	https://doi.org/10.1002/jcsm.13794
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