Early immune responses to intradermal lipopolysaccharide in healthy volunteers: prednisolone’s impact on TLR4-mediated inflammation

BackgroundIntradermal lipopolysaccharide (LPS) administration is a well-established model to investigate Toll-like receptor 4 (TLR4)-mediated inflammation in human skin. Previous studies have shown strong immune activation following LPS injection, including neutrophil influx and cytokine release. Ho...

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Principais autores:	Thomas P. Buters, Digna T. de Bruin, Pieter W. Hameeteman, Wouter ten Voorde, Hendrika W. Grievink, Michelle Osse, Marieke L. de Kam, Jeffrey Damman, Thierry P. P. van den Bosch, Elsa Neubert, Robert Rissmann, Jacobus Burggraaf, Naomi Klarenbeek, Manon A. A. Jansen, Matthijs Moerland
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-05-01
coleção:	Frontiers in Immunology
Assuntos:	corticosteroids dermal human inflammasome (NLRP3) LPS (lipopolysaccharide) neutrophil extra cellular traps
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1724791/full
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