Immunopathology in PMM2-CDG: Defective glycosylation impact in the TNFα -TNFR1 signalling pathway

IntroductionGlycosylation is a post-translational modification that plays a crucial role in immune system activity. Phosphomannomutase 2-Congenital Disorder of Glycosylation (PMM2-CDG) is a rare genetic disease affecting glycosylation with a multi-systemic impact. PMM2-CDG patients commonly show imm...

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Autori principali:	Carlota Pascoal, Pedro Granjo, Rebeka Kodríková, Marta Falcão, Ana C. Santos, Inês Teodoro, Zuzana Pakanová, Marek Nemčovič, Jan Mucha, Margarida Castro-Caldas, Ana R. Grosso, Vanessa dos Reis Ferreira, Paula A. Videira
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-09-01
Serie:	Frontiers in Immunology
Soggetti:	TNF-α fibroblasts PMM2-CDG inflammation transcriptomics glycomics
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1655354/full
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