Type 2 diabetes risk alleles in peptidyl-glycine alpha-amidating monooxygenase influence GLP-1 levels and response to GLP-1 receptor agonists

Abstract Background Type 2 diabetes (T2D) is a leading cause of morbidity and mortality worldwide. Despite the availability of multiple glucose-lowering agents, only half of individuals with T2D achieve the recommended HbA1c target of < 7.0%. Precision medicine approaches that leverage patient-speci...

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Autors principals:	Mahesh M. Umapathysivam, Elisa Araldi, Benoit Hastoy, Adem Y. Dawed, Hasan Vatandaslar, Johanna E. Mayrhofer, Peter Lindquist, Pamuditha N. Silva, Algera Goga, Geraldine O. Trüllinger, Svenja Godbersen, Shahana Sengupta, Adrian Kaufmann, Søren Krogsgaard Thomsen, Bolette Hartmann, Yi-Chun Chen, Anna E. Jonsson, Hasan Kabakci, Swaraj Thaman, Niels Grarup, Christian T. Have, Lindsay P. Pallo, Kristine Faerch, Anette P. Gjesing, Sameena Nawaz, Jane Cheeseman, Matthew J. Neville, Oluf Pedersen, Mark Walker, Han Sun, Christopher Jennison, Andrew T. Hattersley, Jens F. Rehfeld, Rury R. Holman, Bruce C. Verchere, Torben Hansen, Fredrik Karpe, Jens J. Holst, Mette M. Rosenkilde, Angus G. Jones, Michael Ristow, Mark I. McCarthy, Ewan R. Pearson, Markus Stoffel, Anna L. Gloyn
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-03-01
Col·lecció:	Genome Medicine
Accés en línia:	https://doi.org/10.1186/s13073-026-01630-0
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