Transmembrane Batten Disease Proteins Interact With a Shared Network of Vesicle Sorting Proteins, Impacting Their Synaptic Enrichment

Batten disease is unique among lysosomal storage disorders for the early and profound manifestation in the central nervous system, but little is known regarding potential neuron-specific roles for the disease-associated proteins. We demonstrate substantial overlap in the protein interactomes of thre...

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Autors principals:	Mitchell J. Rechtzigel, Brandon L. Meyerink, Hannah Leppert, Tyler B. Johnson, Jacob T. Cain, Gavin Ferrandino, Danielle G. May, Kyle J. Roux, Jon J. Brudvig, Jill M. Weimer
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2022-05-01
Col·lecció:	Frontiers in Neuroscience
Matèries:	lysosome neurodegeneration vesicle traffic Batten disease SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor)
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fnins.2022.834780/full
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