Optimized dicentric chromosome dose–response curves with centromere probes improve low-dose radiation biodosimetry

Abstract Accurate biological dose assessment is critical in radiation emergencies, particularly in cases of low-dose exposure. The dicentric chromosome assay (DCA) is the gold standard for biodosimetry, but conventional Giemsa staining often presents challenges in identifying centromeres, especially...

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Principais autores:	Min Ho Jeong, Hyun Seok Choi, Soo Kyung Jeong, Yeong-Rok Kang, Chang Geun Lee, Hyo Jin Kim, Yong Uk Kye, Jeong-Hwa Baek, Moon-Taek Park, Joong Sun Kim, Su Jung Oh, Wol Soon Jo
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2026-01-01
Serija:	Scientific Reports
Teme:	Biodosimetry Dicentric chromosome assay Giemsa staining Centromere-FISH staining Dose-response curve Minimum detectable dose
Online dostop:	https://doi.org/10.1038/s41598-025-31413-3
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