Galantamine-Curcumin Hybrids as Dual-Site Binding Acetylcholinesterase Inhibitors

Galantamine (GAL) and curcumin (CU) are alkaloids used to improve symptomatically neurodegenerative conditions like Alzheimer’s disease (AD). GAL acts mainly as an inhibitor of the enzyme acetylcholinesterase (AChE). CU binds to amyloid-beta (Aβ) oligomers and inhibits the formation of Aβ plaques. H...

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主要な著者:	Georgi Stavrakov, Irena Philipova, Atanas Lukarski, Mariyana Atanasova, Dimitrina Zheleva, Zvetanka D. Zhivkova, Stefan Ivanov, Teodora Atanasova, Spiro Konstantinov, Irini Doytchinova
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2020-07-01
シリーズ:	Molecules
主題:	virtual screening molecular docking neurotoxicity ADME BBB permeability
オンライン･アクセス:	https://www.mdpi.com/1420-3049/25/15/3341
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