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In Vivo Characterization of the <i>dia</i> Biosynthetic Gene Cluster Reveals Diaporthinic Acid as Its Main Product

The biosynthetic gene cluster (BGC) responsible for producing diaporthinic acid has remained genetically unassigned despite repeated isolation of this metabolite from several fungal species. In this study, we activated the <i>dia</i> BGC in <i>Trichoderma reesei</i> by overexpressing the cluster-ass...

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Principais autores: Isabella Burger, Simon Leonhartsberger, Kathrin Peikert, Lukas Fourtis, Polina Atanasova, Lara T. S. Kramer, Richard Fried, Christian Stanetty, Florian Rudroff, Ruth Birner-Gruenberger, Robert L. Mach, Astrid R. Mach-Aigner, Matthias Schittmayer, Christian Zimmermann
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-06-01
Serier:Journal of Fungi
Fag:
ascomycetes
<i>Aspergillus oryzae</i>
gene expression
secondary metabolism
transcription factor
regulation
Online adgang:https://www.mdpi.com/2309-608X/12/6/402
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