CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance

Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must enter the medulla to test their T-cell receptors (TCRs) for autoreactivity against the diverse self-antigens display...

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Principais autores:	Yu Li, Pablo Guaman Tipan, Hilary J Selden, Jayashree Srinivasan, Laura P Hale, Lauren IR Ehrlich
格式:	Artigo
语言:	Inglês
出版:	eLife Sciences Publications Ltd 2023-06-01
丛编:	eLife
主题:	CCR4 CCR7 central tolerance negative selection chemokine receptors thymocytes
在线阅读:	https://elifesciences.org/articles/80443
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