idh-1 neomorphic mutation confers sensitivity to vitamin B12 in Caenorhabditis elegans
Replicating human cancer-associated variant of isocitrate dehydrogenase in C. elegans causes embryonic lethality upon vitamin B12 supplementation due to increased dependency on one-carbon metabolism. In humans, a neomorphic isocitrate dehydrogenase mutation ( idh-1neo ) causes increased levels of ce...
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| Huvudupphov: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
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Life Science Alliance LLC
2024-10-01
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| Serie: | Life Science Alliance |
| Länkar: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202402924 |
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