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Identification and characterization of new structural scaffolds modulating the activity of Mycobacterium tuberculosis dihydroneopterin aldolase (FolB) in vitro

IntroductionAntifolates were among the first broad-spectrum compounds used as antimycobacterial agents and can still be of use when no other therapeutic options are available. The discovery of compounds targeting the essential folate synthesis pathway could lead to new therapeutic agents to treat tu...

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Principais autores: Virginia Carla de Almeida Falcão, Alexia de Matos Czeczot, Mohammad Maqusood Alam, Kyu-Ho Paul Park, Jinyeong Heo, Minjeong Woo, Ana Micaela Camini, Luis Fernando Saraiva Macedo Timmers, David Shum, Marcia Alberton Perelló, Luiz Augusto Basso, Pablo Machado, Cristiano Valim Bizarro, Vincent Delorme
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-06-01
coleção:Frontiers in Tropical Diseases
Assuntos:
Mycobacterium tuberculosis
dihydroneopterin aldolase (DHNA)
Rv3607c (FolB)
folate precursor synthesis
drug screening
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fitd.2024.1402321/full
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