Establishing the first Afro-Caribbean breast cancer cell lines reveals ECM pathway enrichment and distinctive drug sensitivities

Abstract Women of African ancestry develop more aggressive breast cancer (BCa) with poorer survival outcomes, yet only 8% of available cell lines represent this population, impeding targeted treatment development. Here, we aimed to establish and characterize new cell lines from an Afro-Caribbean pat...

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Автори:	Shannique Clarke, Isabella Allen, Jovanka Ravix, Maycon Marção, Felipe Carcanholo, Albert Doughan, Alex Sanchez-Covarrubias, Derria Cornwall, Sharon Harrison, Claude-Henry Volmar, Shannon Saigh, Daniel Bilbao, Jasmine Plummer, Elizabeth Smith, Rory Thompson, Camille Ragin, Sophia George, Simone Badal
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Nature Portfolio 2026-05-01
Серія:	Scientific Reports
Предмети:	African ancestry Cancer health disparities Triple-negative breast cancer Therapeutic response Tumour heterogeneity Patient-derived models
Онлайн доступ:	https://doi.org/10.1038/s41598-026-51649-x
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Establishing the first Afro-Caribbean breast cancer cell lines reveals ECM pathway enrichment and distinctive drug sensitivities

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