Broad-Spectrum Gramicidin S Derivatives with Potent Activity Against Multidrug-Resistant Gram-Negative ESKAPE Pathogens

Background/Objectives: Multidrug-resistant Gram-negative ESKAPE pathogens, including <i>E. coli</i>, <i>K. pneumoniae</i>, <i>P. aeruginosa</i>, and <i>A. baumannii</i>, pose a significant global health threat. Gramicidin S, a potent cyclic antimicrobial peptide, is largely ineffective against these...

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Autori principali:	John T. Kalyvas, Yifei Wang, Ornella Romeo, John R. Horsley, Andrew D. Abell
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2025-04-01
Serie:	Antibiotics
Soggetti:	antibiotic resistance antimicrobial peptides antibiotics gramicidin S broad-spectrum ESKAPE pathogens
Accesso online:	https://www.mdpi.com/2079-6382/14/5/423
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