Cellular and molecular determinants mediating the dysregulated germinal center immune dynamics in systemic lupus erythematosus

IntroductionSystemic lupus erythematosus (SLE) is characterized by dysregulated humoral immunity, leading to the generation of autoreactive B cells that can differentiate both within and outside of lymph node (LN) follicles.MethodsHere, we employed spatial transcriptomics and multiplex imaging to in...

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Bibliografische gegevens

Hoofdauteurs:	Spiros Georgakis, Kalliopi Ioannidou, Bernat Bramon Mora, Michail Orfanakis, Cloe Brenna, Yannick D. Muller, Perla M. Del Rio Estrada, Ashish A. Sharma, Giuseppe Pantaleo, Laurence de Leval, Denis Comte, Raphael Gottardo, Constantinos Petrovas
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Frontiers Media S.A. 2025-02-01
Reeks:	Frontiers in Immunology
Onderwerpen:	T follicular helper cells (TFH) type I IFN age-associated B cells germinal center response IL-4 systemic lupus erythematosus (SLE)
Online toegang:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1530327/full
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