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Role of hypoxia and growth and differentiation factor-5 on differentiation of human mesenchymal stem cells towards intervertebral nucleus pulposus-like cells

There is evidence that mesenchymal stem cells (MSCs) can differentiate towards an intervertebral disc (IVD)-like phenotype. We compared the standard chondrogenic protocol using transforming growth factor beta-1 (TGFß) to the effects of hypoxia, growth and differentiation factor-5 (GDF5), and cocultu...

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Hlavní autoři: JV Stoyanov, B Gantenbein-Ritter, A Bertolo, N Aebli, M Baur, M Alini, S Grad
Médium: Artigo
Jazyk:Inglês
Vydáno: Forum Multimedia Publishing LLC 2011-06-01
Edice:European Cells & Materials
Témata:
Stem cells
chondrogenesis
tissue engineering
intervertebral disc
nucleus pulposus
signalling molecules
growth factors
On-line přístup:http://www.ecmjournal.org/journal/papers/vol021/pdf/v021a40.pdf
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