Region-specific glial homeostatic signature in prion diseases is replaced by a uniform neuroinflammation signature, common for brain regions and prion strains with different cell tropism

Chronic neuroinflammation is recognized as a major neuropathological hallmark in a broad spectrum of neurodegenerative diseases including Alzheimer's, Parkinson's, Frontal Temporal Dementia, Amyotrophic Lateral Sclerosis, and prion diseases. Both microglia and astrocytes exhibit region-specific home...

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Автори:	Natallia Makarava, Jennifer Chen-Yu Chang, Kara Molesworth, Ilia V. Baskakov
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Elsevier 2020-04-01
Серія:	Neurobiology of Disease
Предмети:	Neurodegenerative diseases Prion diseases, Chronic neuroinflammation Reactive microglia Reactive astrocytes Thalamus Prion strains
Онлайн доступ:	http://www.sciencedirect.com/science/article/pii/S0969996120300589
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