The Roles of PCSK9 in Alzheimer’s Disease: A Systematic Review of Clinical, Genetic, and Preclinical Evidence

Alzheimer’s disease (AD) is increasingly associated with alterations in cholesterol metabolism. Proprotein convertase subtilisin/kexin type 9 (PCSK9), an enzyme regulating low-density lipoprotein receptor (LDLR) degradation, has been implicated in AD through mechanisms involving amyloid-β (Aβ) proce...

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Principais autores:	Vicko Suswidiantoro, Meidi Utami Puteri, Mitsuyasu Kato, Donna Maretta Ariestanti, Richard Johari James, Fadlina Chany Saputri
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2025-12-01
Series:	Life
Assuntos:	Alzheimer’s disease amyloid-β cholesterol neurodegeneration PCSK9
Acceso en liña:	https://www.mdpi.com/2075-1729/15/12/1851
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