The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy

Abstract As our understanding of the mechanisms of cancer treatment has increased, a growing number of studies demonstrate pathways through which DNA damage repair (DDR) affects the immune system. At the same time, the varied response of patients to immune checkpoint blockade (ICB) therapy has promp...

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Hlavní autoři:	Congqi Shi, Kaiyu Qin, Anqi Lin, Aimin Jiang, Quan Cheng, Zaoqu Liu, Jian Zhang, Peng Luo
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2022-09-01
Edice:	Journal of Experimental & Clinical Cancer Research
Témata:	DNA damage repair DNA damage repair inhibitors Immune checkpoint inhibitor Immune checkpoint blockade cGAS/STING ATM/ATR/Chk1
On-line přístup:	https://doi.org/10.1186/s13046-022-02469-0
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