Long-Term Toxicity Study of Topical Administration of a Highly-Stable rh-aFGF Carbomer 940 Hydrogel in a Rabbit Skin Wound Model

We developed a highly stable recombinant human acidic fibroblast growth factor (rh-aFGF) carbomer 940 hydrogel for wound healing. This study aimed to reveal toxicity target organs and the toxicity dose-response in the long-term administration of rh-aFGF carbomer 940 hydrogel in a rabbit skin wound m...

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Autori principali:	Li Zhang, Tongzhou Huang, Jianing Bi, Yingying Zheng, Chao Lu, Qi Hui, Xiaojie Wang, Xiaohua Lin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2020-02-01
Serie:	Frontiers in Pharmacology
Soggetti:	rh-aFGF carbomer 940 hydrogel long-term toxicity immunotoxicity neutralization antibody
Accesso online:	https://www.frontiersin.org/article/10.3389/fphar.2020.00058/full
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